A versatile SERS platform based on conductive MOF-enforced carbon paper for rapidly and sensitively monitoring diazepam in aquatic products

Abstract

Herein, a versatile surface enhanced Raman scattering (SERS) platform was firstly constructed by integrating conductive metal organic framework (CMOF) with controlled electrodeposition of Au nanoparticles (Au NPs) on flexible carbon paper (CP-CMOF@Au) for sensitively recognizing diazepam (DZP) in aquatic products. The CMOF not only provided a pre-concentration effect for boosting sensitivity, but also dramatically improved the intrinsic electrical conductivity contributing to homogeneous distribution of Au NPs and forming SERS-active “hot spot” with superior stability and reproducibility. Based on CP-CMOF@Au chip, DZP can be sensitively detected with low limit of detection of 0.64 ng mL−1 and wide linear detection range from 0.001 to 10 μg mL−1. Also, DZP in aquatic products can be collected and recognized using multiple approaches (drip coating, soaking and wiping) with excellent reusability and satisfactory recovery of 85.8–103.3%. This method would provide an ingenious SERS strategy for rapidly monitoring DZP in aquatic products with good practical applicability.