Abstract
Spike sorting technologies support neuroscientists to access the neural activity with single-neuron or single-action-potential resolutions. However, conventional spike sorting technologies perform the feature extraction and the clustering separately after the spikes are well detected. It not only induces many redundant processes, but it also yields a lower accuracy and an unstable result especially when noises and/or overlapping spikes exist in the dataset. To address these issues, this paper proposes a unified optimization model integrating the feature extraction and the clustering for spike sorting. Unlike the widely used combination strategies, i.e., performing the principal component analysis (PCA) for spike feature extraction and the K-means (KM) for clustering in sequence, interestingly, this paper finds the solution of the proposed unified model by iteratively performing PCA and KM-like procedures. Subsequently, by embedding the K-means++ strategy in KM-like initializing and a comparison updating rule in the solving process, the proposed model can well handle the noises and overlapping interference as well as enjoy a high accuracy and a low computational complexity. Finally, an automatic spike sorting method is derived after taking the best of the clustering validity indices into the proposed model. The extensive numerical simulation results on both synthetic and real-world datasets confirm that our proposed method outperforms the related state-of-the-art approaches.
Highlights
E XTRACELLULAR cortical recording with silicon singleor tetrodes-microelectrodes plays an irreplaceable role in studying the information processing mechanisms within the nervous system [1], [2], which are beneficial in broad scopes of applications like neural prosthetics [3], brainmachine interfaces [4], treating epilepsy [5], etc
The proposed automatic spike sorting method is evaluated on both several well-known simulated datasets and a real tetrode recorded dataset. It is compared with several related state-of-the-art spike sorting methods based on different evaluation criteria
The waveforms were issued by three neurons in the neocortex and basal ganglia [40], and the noise was mimicked by randomly selecting the real recorded signal with different amplitudes issued by different neurons [14]
Summary
E XTRACELLULAR cortical recording with silicon singleor tetrodes-microelectrodes plays an irreplaceable role in studying the information processing mechanisms within the nervous system [1], [2], which are beneficial in broad scopes of applications like neural prosthetics [3], brainmachine interfaces [4], treating epilepsy [5], etc. These applications require the neural activity with singleneuron or single-action-potential resolutions, these electrodes record the activities from multiple neurons surrounding the electrode [5], [6]. Features extracted in a low dimensional space (in Fig. this dimension is 2) and clustering the featured spikes are needed, which are quite challenging compared with the filtering and detection stages [10]
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