A tunable multitasking renal function assessment biosensor predicated on cylindrical metastructure

Abstract

Chronic renal disease has become one of the world’s most serious public health problems in recent decades, leading to physical degradation, and even death. Glucose and creatinine in body fluids are important indicators used to assess renal dysfunction, but current biosensors only focus on the detection and performance improvement of a single indicator. To break through the idea limitation, a cylindrical metastructure based on indium antimonide material is proposed in this paper. It innovatively realizes the tunable multitasking renal function assessment biosensor, which is more suitable for the application of multiple medical detection scenarios. Through the control of the external magnetic field strength, the glucose concentration of 0 ∼ 400 g/L and the serum creatinine concentration of 80.9 ∼ 85.28 μmol/L can be separately detected in real-time, unlabeled, and non-destructively, which own better performance than previous renal function assessment biosensors in terms of detection range, R2, quality factor, figure of merit, and detection limit. This proposal has important reference value for promoting the detection and treatment of renal diseases, and the research of multitasking biosensors.