Abstract
The level of HClO/ClO− in mitochondria is essential to keep the normal function of mitochondria. Therefore, it is meaningful to accurately and quickly monitor ClO− in mitochondria. In this work, a new triphenylamine-based fluorescence probe PDTPA was designed and synthesized, in which pyridinium salt and dicyano-vinyl group were introduced as mitochondria targeting site and reaction site for ClO−. The probe showed high sensitivity and fast fluorescence response (<10 s) in the detection of ClO−. Moreover, the probe PDTPA had good linearity in a wide concentration range of ClO− and its detection limit was calculated as 10.5 μM. Confocal fluorescence images demonstrated that the probe could target mitochondria and track the fluctuations of endogenous/exogenous ClO− levels in the mitochondria of living cells.
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