Abstract
The recently published ATPCI study resulted in the safety of trimetazidine administered immediately after successful revascularization but was not more effective (cardiovascularis death, recurrence of angina, hospitalization for cardiac event) than the randomized double-blind placebo. A retrospective analysis of our previously published ONECAPS open-label observational study was performed to determine whether there was a difference in the efficacy of trimetazidin prolong in the angina patients according to whether or not they had previously undergone revascularization. Of the 1670 angina patients, 1008 were not revascularized, while 662 had previously undergone revascularization. There was no difference in age or comorbidity between the two groups. Patients were examined for changes in weekly angina, short-acting nitroglycerin use and angina severity during once-daily administration of trimetazidine prolong 80 mg in revascularized and non-revascularized study groups. In both the revascularized and non-revascularized group, trimetazidine resulted in a significant reduction (p<0.0001) in both weekly angina count and short-acting nitroglycerin use. In addition, the proportion of angina with Canadian Cardiovascular Society (CCS) I increased and the proportion of CCS III and CCS IV decreased in both patient groups as well. All of this effect was achieved with statin, ACEI/ARB, and beta-blocker use above 90% in revascularized patients. Trimetazidine prolong 80 mg once daily significantly reduced the number of angina per week, the use of short-acting nitroglycerin per week, and the severity of angina. This effect is independent of whether the patient has previously received revascularization. Orv Hetil. 2021; 162(29): 1167-1171.
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