Abstract
High-frequency electrical stimulation (HFS) of C fiber nociceptors induces long-term potentiation (LTP) at the first spinal synapse. This spinal LTP is believed to play a role in the amplification of pain. However, the effects of HFS are probably not restricted to the spinal cord. A recent study showed that HFS increases cortical responses to noxious stimuli in a porcine model. Are these increased cortical responses a correlate of spinal LTP and do we observe the same in humans?
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