Abstract
In this work a 40 mm cube of an optically clear, radio-fluorogenic gel composed of partially-polymerized tertiary-butyl acrylate and maleimido-pyrene (∼0.01%) is irradiated with orthogonally-crossed, 10 mm square and round, 200 kVp x-ray beams. A thin sheet of UV light is produced between two parallel plates with 2 mm slits illuminated by collimated, linear-array, LED sources. The gel is transported 1 mm at a time through the UV sheet and the fluorescence from the emissive, polymeric radiolytic product formed in the x-ray tracks is recorded, as both JPEG and raw-DNG files, using a CCD camera placed orthogonal to the plane of the excitation light. The resulting stack of 40 tomographic slices are imported into freely-available software to produce 3D animated images of the radiation-induced fluorescence.
Highlights
A method capable of monitoring the energy deposited by ionizing-radiation in three-dimensions with millimeter spatial resolution is a longstanding wish of clinical radiation physicists for quality assurance (QA) auditing of the increasingly complex computerdesigned protocols used for patient treatment (Ibbott and Thwaites 2015, Kron et al 2016)
We present here recent results of a method not previously reviewed that is capable of providing fluorescent 3D images of complex radiation fields with submillimetre spatial resolution (Warman et al 2011, 2013)
In this report we demonstrate how the three-dimensional fluorescent image created in such a gel by orthogonally-crossed round and square x-ray beams can be reconstructed using a tomographic fluorescence scanning technique
Summary
A method capable of monitoring the energy deposited by ionizing-radiation in three-dimensions with (sub) millimeter spatial resolution is a longstanding wish of clinical radiation physicists for quality assurance (QA) auditing of the increasingly complex computerdesigned protocols used for patient treatment (Ibbott and Thwaites 2015, Kron et al 2016). We present here recent results of a method not previously reviewed that is capable of providing fluorescent 3D images of complex radiation fields with submillimetre spatial resolution (Warman et al 2011, 2013). The method is based on radio-fluorogenic (RFG) co-polymerization by which a fixed fluorescent image of a complex radiation field is produced within an otherwise clear and tissue-equivalent gel.
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