Abstract
The behavior of cavitation bubbles in tissue driven by ultrasonic fields is an important problem in biomedical acoustics. The present solution combines the Keller‐Miksis equation for nonlinear bubble dynamics with the linear Voigt model for viscoelastic media and experimental values for the model’s parameters (rigidity G=0, 0.5 – 2.5 MPa and viscosity μ=0.005 or 0.015 Pa⋅s). Two and 3‐component models are used to study the oscillations of gas bubbles in tissue and in partially digested tissue. Numerical computations are performed for a variety of cases. Inertial cavitation thresholds (Pt) are determined for various equilibrium radii, frequencies and threshold criteria. Bubble‐induced tissue displacement and strain is also investigated for several representative tissue types. It is found that: 1) thresholds in tissue are up to 10 times those in liquid, 2) Pt increases nearly linearly with frequency, 3) there is an optimal relation between the microbubble and tissue radii that maximizes the displacement of the tissue adjacent to the bubble and thus the likelihood of tissue damage.
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