Abstract
SARS-CoV-2 infections are initiated by attachment of the viral receptor-binding domain (RBD) to angiotensin-converting enzyme-2 (ACE2) on human host cells. This critical first step occurs in the dynamic environment of the respiratory tract, where external forces constantly act on the binding partners, making stable attachment crucial for effective infection. Understanding the molecular mechanisms of this process would enable targeted interventions. Thus, there is an urgent need for assays that can quantitate SARS-CoV-2 interactions with ACE2 under mechanical load.
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