A Technical process of phytoconstituents extraction using Hydrotropes: Green and Sustainable Approach

Abstract

Background: The design of green and sustainable extraction methods of natural products is currently a prime topic in the multidisciplinary area of applied chemistry, biology, and technology, with the growing consumer demand for greener alternatives that do not involve any chemicals and industry concerns of sustainable, nontoxic extraction routes, the application of novel extraction technologies in the drug industry have been widely studied. Hydrotrope has fewer toxic effects, is economically friendly, and is independent of pH. These compounds can enhance the bioavailability, solubility, dissolution, extraction yield, and purity of extracted phytoconstituents. Conclusion: The recent review illustrates the extensive references to the novel extraction of Phyto active compounds through hydrotrope and depicts the summary of updated extraction technologies. The technique is recent, simple, less expensive, and environmentally advantageous. Updated advanced extraction methods like ultrasound-assisted hydrotropic extraction (UAHE), microwave-assisted hydrotropic extraction (MAHE), and ultrasonic microwave-assisted hydrotropic extraction (UMAHE) have been considered a clean, green, and efficient alternatives to conventional extraction technologies. The active phytoconstituents extraction using hydrotrope with advanced extraction technologies has claimed to enhance the extraction yield up to 99% compared with the extraction involving organic solvent of such bioactive. Consequently, when carried out at a reduced temperature, hydrotropic extraction provided a higher extraction yield in a lesser time and maintained the purity of phytoconstituents.