A Team for Unique Molecular Imaging Based in South Africa.

Abstract

This invited Team Profile was created by the Ebenhan Lab (Professor Thomas Ebenhan and Professor Jan Rijn Zeevaart) at the Preclinical Imaging Facility, Nuclear Medicine Research Infrastructure (NuMeRI) NPC, Pretoria (South Africa) in collaboration with Arno C. Gouws, Professor Hendrik G. Kruger, and Professor Tricia Naicker from the Catalysis and Peptide Research Unit at the University of KwaZulu Natal, Durban (South Africa); Professor Olivier Gheysens from the Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research, Université Catholique de Louvain, Brussels (Belgium); and ProfessorThavendran Govender from the Department of Chemistry, University of Zululand, KwaDlangezwa (South Africa). Researchers at these institutes have a 10-year track record of joint publications. The review written by this collaboration provides a summary of the relevant antibiotic-derived PET radiotracers, grouped either by radiotracer development for infection imaging, or radio-antibiotic PET imaging for pharmacologic drug characterization. The review includes a critical, in-depth evaluation, addressing the challenges and pitfalls of developing antibiotic-derived PET radiotracers as infection imaging agents. "Antibiotic-Derived Radiotracers for Positron Emission Tomography: Nuclear or 'Unclear' Infection Imaging?", A. C. Gouws, H. G. Kruger, O. Gheysens, J. R. Zeevaart, T. Govender, T. Naicker, T. Ebenhan, Angew. Chem. Int. Ed. 2022, e202204955.