A Takagi–Sugeno fuzzy controller for minimizing cancer cells with application to androgen deprivation therapy

Abstract

Androgen deprivation therapy (ADT) is frequently used to treat prostate cancer which is a widespread disease having a very low survival rate. A prolonged course of ADT can increase toxicity and drug resistance. This study proposes an adaptive therapy combining chemotherapy or immunotherapy with the discontinuation of hormone therapy to overcome these obstacles. The super-twisting sliding mode control (STSMC) algorithm is found to be one of the effective approach as an ADT model for obtaining suitable dosage adaptively. The primary objective is to rapidly reduce the number of cancer cells and the duration of drug exposure. The Takagi–Sugeno fuzzy controller-based active control algorithm is introduced, and it’s performance is compared with the STSMC algorithm. While maintaining global asymptotic stability, the Takagi–Sugeno fuzzy controller reduces the duration of therapy to six months. The controllers are implemented utilizing the linear matrix inequality (LMI) algorithm and the yet another LMI (YALMIP) toolset for MATLAB, and their efficacy is validated utilizing MATLAB and Simulink simulations. This study presents a novel approach to improve prostate cancer treatment outcomes by integrating nonlinear control algorithms and adaptive dosage strategies to reduce treatment duration and minimize drug exposure, thereby improving patient outcomes in prostate cancer management.