A Systematic Review of Long Noncoding RNAs in Hepatocellular Carcinoma: Molecular Mechanism and Clinical Implications.

Xiaoge Hu,Qiuran Xu,Jiahong Jiang,Dongsheng Huang,Chao Ni,Liu Yang

doi:10.1155/2018/8126208

Abstract

Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide among all cancers. Previous studies have revealed the significant involvement of long noncoding RNAs (lncRNAs) in numerous human cancers including HCC. Both oncogenic and tumor repressive lncRNAs have been identified and implicated in the complex process of hepatocarcinogenesis. They can be further explored as prospective diagnostic, prognostic, and therapeutic markers for HCC. An in-depth understanding of lncRNAs' mechanism in HCC is therefore required to fully explore their potential role. In the current review, we will concentrate on the underlying function, molecular mechanisms, and potential clinical implications of lncRNA in HCC.

Highlights

Among all cancers, hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide [1]
It is vital to illustrate the molecular mechanism of HCC in order to improve diagnosis, treatment, and overall prognosis
The long ncRNAs with more than 200 nucleotides play significant roles in cell growth and differentiation, chromatin organization, and regulation of gene expression [7, 8]. lncRNAs are classified into intronic, intergenic, sense, and antisense types based on their genomic location [9] and into signaling, decoy, guide, and scaffold lncRNAs on a functional basis [10]

Summary

Introduction

Hepatocellular carcinoma (HCC) has the second highest mortality rate worldwide [1]. HOTAIR enhances proliferation, migration, glycolysis, autophagy, and chemoresistance in HCC cells (Table 1). FOXC1 upregulated HOTAIR in HCC cells via miR-1 inhibition, thereby increasing proliferation [30].

Results

Conclusion