A systematic review and meta-analysis of cherry (Prunus spp.) consumption on glycemic markers and lipid profile

Abstract

Cherry fruit (Prunus spp.) has gained growing attention in cardiometabolic health mainly due to its bioactive compounds, including anthocyanins and phenolic acids. However, the effectiveness of cherries on makers of cardiovascular health has been controversial yet. The present report aimed to summarize the effect of cherry consumption on glycemic markers and lipid profile in adults. Four databases were searched up to June 2021. Randomized controlled trials (RCTs) investigating the effects of tart or sweet cherries on glycemic markers (fasting blood glucose, fasting insulin, and HOMA-IR) and serum lipids (triglycerides, total cholesterol, low-density lipoprotein-cholesterol, and high-density lipoprotein-cholesterol) were included in the meta-analysis. Seven RCTs were included in the meta-analysis. Meta-analysis revealed that cherry had no significant effects on glycemic markers or lipid profile. Although, in subgroup analysis, cherry significantly decreased serum total cholesterol in subjects with a mean body mass index (BMI) ranging between 25 and 29.9 kg/m 2 (WMD: -14.40 mg/dl, 95% CI: - 27.33, - 1.48), and serum triglycerides in those with mean BMI ≥30 kg/m 2 (WMD: - 17.65 mg/dl, 95% CI: - 24.70, - 10.59). Overall, this meta-analysis showed no significant effects of cherry consumption on glycemic markers and lipid profile. • Overall, cherry had no significant effect on glycemic markers or blood lipids. • Cherry significantly decreased total cholesterol in overweight individuals. • Cherry decreased serum triglycerides significantly in obese individuals.