A survey on the increased blood PTH among community residents in Urumqi

Abstract

Objective To investigate the status of increased blood parathyroid hormone(PTH)level among community residents in Urumqi, and to analyze its correlation with the metabolic parameters including serum Ca and P levels. Methods In May 2013, a cross-sectional survey was conducted, when 1 473 permanent residents in Urumqi, including 844 Han and 629 Uyghurs, were selected by cluster random sampling. PTH and 25-OH vitamin D[25(OH)D] levels were detected by chemiluminescence. Blood Ca, P, Mg, albumin, and creatinine(Cr)were also measured. Based on serum 25(OH)D level, the residents were divided into vitamin D deficiency(<20 ng/ml), vitamin D insufficiency(≥20 and <30 ng /ml), and vitamin D sufficiency(≥30 ng/ml)groups. According to the PTH level, the residents were divided into PTH < 65 pg/ml group and PTH≥65 pg/ml group. The metabolic parameters including Ca and P were compared among different ethnic groups. Results In the surveyed population, the rate of increased blood PTH was 12.22%, being higher in females than that in males(13.82% vs 8.45%, P=0.004)and higher in Han Chinese than that in Uyghurs(19.87% vs 6.52%, P<0.01). The proportions of residents with vitamin D sufficiency, insufficiency and deficiency were 3.34%, 9.06%, and 87.60% in Uyghurs, and 10.43%, 29.98%, and 59.60% in Han, respectively. The rate of 25(OH)D deficiency was significantly higher in Uyghurs than that in Han(P<0.01), especially higher in female Uyghurs(91.43%). In vitamin D deficiency group, the rate of increased serum PTH was significantly increased, higher in Uyghurs than that in Hans(22.14% vs 6.56%, P<0.01), which revealed a negative correlation with 25(OH)D(r=-0.251, P< 0.01). Conclusion 25(OH)D deficiency is prevalent among the community population in Urumqi, with ethnic differences in serum PTH level and the rate of increased blood PTH, which might be associated with vitamin D deficiency. (Chin J Endocrinol Metab, 2018, 34: 295-299) Key words: Parathyroid hormone; 25-Hydroxyvitamin D; Uyghurs; Han