Abstract
Most common limitations of drug carriers, such as liposomes, are low Encapsulation Efficiency (EE) and possible degradation of the encapsulated drugs. Several techniques were developed to overcome these problems; among these, Supercritical assisted Liposome formation (SuperLip) is a CO2-mediated technique to produce liposomes at nanometric level.SuperLip was employed to produce amoxicillin-loaded liposomes. Vesicles have been loaded with 1, 5, 10 and 20 % (w/w) amoxicillin to lipid ratio; then, 1 % (w/w) cholesterol/lipid was added to liposomes lamellae. Liposomes showed mean diameters of about 200 nm and EE up to 84 %.Antimicrobial effect of amoxicillin-loaded liposomes on Escherichia coli was studied. E. coli growth was monitored inoculating bacteria in Luria-Bertani medium with different liposome concentrations (25, 50 and 100 ppm) and different antibiotic/lipid ratio (5, 10 and 20 %, w/w). An increase in the amoxicillin/lipid ratio enhanced growth inhibition of E. coli, especially at 100 ppm of dosage.
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