A Successful Live Birth with In Vitro Fertilization from a Woman with a Huge Uterus Due to Recurrent Multiple Uterine Fibroids after Abdominal Myomectomies

Abstract

We report a successful live birth with in vitro fertilization (IVF) from a woman with an extremely huge uterus. A 30-year-old woman with an uterus of approximately 13×10×12 cm3 due to recurrent multiple fibroids after two myomectomies presented to our hospital with a desire to become pregnant. She has undergone one cycle of fresh embryo transfer and two cycles of frozen-thawed embryo transfer following Gonadotropin-releasing hormone (GnRH) agonists treatment. The IVF procedures for the woman resulted in a pregnancy that leaded to a live birth of a healthy male baby weighing 3400 g delivered at 39 weeks. Thus, we concluded that for women with huge uterus and multiple fibroids, or otherwise unexplained infertility, assisted reproduction might lead to pregnancy and live birth, even if previous myomectomy and GnRH agonists treatment didn’t exhibit beneficial effects on fibroids.