Abstract
In this research, a new nano drug-based multi-walled carbon nanotubes (MWCNTs) was prepared and evaluated qualitatively. Bromocriptine (BRC) was conjugated to functionalized carbon nanotubes. Then, the CHNS, FT-IR, SEM, and RAMAN tests for characterization of the conjugated drug were done. The nanofluid-containing nano-drug was evaluated on lung cancer cells (A549 & QU-DB) and MRC5 by MTT and flow cytometry tests. Then, the gene expression studies of dopamine receptor genes were done before and after nano-drug treatment. After that, a western blotting test was carried out for further investigation of dopamine receptors protein production. Finally, Bax and Bcl-2 secretion were measured by the ELISA method in cells affected by MWCNTs-BRC Nf compared to untreated cells. The results showed that the nano-drug had a significant lethal effect on cancer cells, while it had no toxicity on MRC5. Also, the nano-drug could significantly induce apoptosis in lung cancer cells at a lower dose compared to the drug alone. In this study, a targeted nano-drug delivery system was designed, and its performance was evaluated based on neurotransmitter pathways, and the results showed that it may be useful in the treatment of lung cancer. However, additional studies on animal models are underway.
Highlights
In this research, a new nano drug-based multi-walled carbon nanotubes (MWCNTs) was prepared and evaluated qualitatively
The results of the elemental analysis confirmed amid binding of drugs to the CNTs because detectable amounts of nitrogen compared to carboxylated CNTs did not contain any nitrogen
The modifications of MWCNT samples were investigated by scanning electron microscope (SEM)
Summary
A new nano drug-based multi-walled carbon nanotubes (MWCNTs) was prepared and evaluated qualitatively. A targeted nano-drug delivery system was designed, and its performance was evaluated based on neurotransmitter pathways, and the results showed that it may be useful in the treatment of lung cancer. BRC binds to receptor D2 and inhibits prolactin secretion, and is used to treat Parkinson’s disease, type 2 diabetes, hyperprolactinemia, cocaine addiction, and neuroleptic malignant syndrome[9] These conditions are due to a decrease in dopamine secretion from a specific area of the brain. Previous studies have shown that the expression profile of dopamine receptor genes in people with lung cancer is different from that in healthy people. Common treatments of lung cancer include drug treatment, radiotherapy, chemotherapy, surgery and targeted therapy, and immunotherapy New methods, such as drug delivery systems and the use of nano drugs, have been widely considered
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