Abstract
IL-22 is a cytokine produced by T cells and innate lymphocytes. Its receptor is exclusively expressed by non hematopoietic cells mostly epithelial cells and hepatocytes. IL-22 has pathogenic or protective effects depending on the model. A role for IL-22 is suggested in IMID such as psoriasis, rheumatoid arthritis and Crohn disease. IL-22BP is a soluble inhibitory receptor specific for IL-22 whose cellular source and physiological role are mainly unknown.
Highlights
IL-22 is a cytokine produced by T cells and innate lymphocytes
IL-22BP mRNA was expressed at high levels in rat secondary lymphoid organs and intestine
IL-22BP mRNA was restricted to a CD4+SIRPA+ subset of dendritic cells (DCs)
Summary
IL-22 is a cytokine produced by T cells and innate lymphocytes. Its receptor is exclusively expressed by non hematopoietic cells mostly epithelial cells and hepatocytes. IL-22 has pathogenic or protective effects depending on the model. A role for IL-22 is suggested in IMID such as psoriasis, rheumatoid arthritis and Crohn disease. IL-22BP is a soluble inhibitory receptor specific for IL-22 whose cellular source and physiological role are mainly unknown. Aims To identify the cellular source of IL-22BP in vivo and its regulation of expression
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