Abstract
Background: High concentrations of maternal C-reactive protein have been associated with adverse pregnancy outcome, and premature uterine contraction may be predicted by elevated levels of C-reactive protein.
 Methods: Hospital based comparative analysis was conducted on women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method.
 Results: The mean c-reactive protein level in cases 2.23 with min-max value ranging from 0.82-3.94 mg/dl while in controls mean c-reactive protein value came to be 9.15 with min-max range from 3.11-24.9mg/dl.
 Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies.
 Keywords: Diagnostic, CRP, Pregnancy, Women.
Highlights
Pregnancy is described as first 12 weeks from beginning of the last menstural period to the end of first three months
The mean c-reactive protein level in cases 2.23 with minmax value ranging from 0.82-3.94 mg/dl while in controls mean c-reactive protein value came to be 9.15 with minmax range from 3.11-24.9mg/dl
Mean c-reactive protein levels were higher among controls showing that a higher c-reactive protein level was seen among pregnant women in early gestation with normal intrauterine pregnancy when compared to abnormal ones
Summary
Pregnancy is described as first 12 weeks from beginning of the last menstural period to the end of first three months. In first trimester, raised CRP levels have been reported and more recently it was shown that women with higher CRP levels at 9-13 weeks are more likely to develop gestational diabetes mellitus and pre-eclampsia.[3]. It has been shown that CRP is present in amniotic fluid and fetal urine, and the elevated levels are associated with adverse pregnancy outcome. These results demonstrate releases CRP, that the like other human placental placenta proteins, produces mainly into a-tnhde maternal circulation
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