Abstract
Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women
 Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy. C-reactive protein (CRP) quantitative estimation is done by turbi-diametric method. Collected samples were sent to a designated lab of our hospital.
 Results: The mean c-reactive protein level in cases 2.31 with min-max value ranging from 0.80-3.91mg/dl while in controls mean c-reactive protein value came to be 9.12 with min-max range from 3.21-24.16 mg/dl. The difference between the two groups is significant as p value is less than 0.001.
 Conclusion: Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies.
 Keywords: CRP, Pregnancy, Women
Highlights
In first trimester, raised C-reactive protein (CRP) levels have been reported and more recently it was shown that women with higher CRP levels at 9-13 weeks are more likely to develop gestational diabetes mellitus and pre-eclampsia.[1]
Background: To Assess Predictive Role of C-Reactive Protein In Early Pregnancy among Women Methods: Hospital based comparative analysis was conducted on Women with early pregnancy upto 14 weeks with either abdominal pain or vaginal bleeding or suspected extrauterine pregnancy
Our results of significantly increased CRP levels in normal pregnancy and a clear association between CRP and normal pregnancy, support the clinical application of this diagnostic tool in early pregnancy, especially as a predictor of abnormal first trimester pregnancies
Summary
In first trimester, raised CRP levels have been reported and more recently it was shown that women with higher CRP levels at 9-13 weeks are more likely to develop gestational diabetes mellitus and pre-eclampsia.[1] It is not possible to assess the maternal fetal interface in ongoing or threatened pregnancies directly. It has been shown that CRP is present in amniotic fluid and fetal urine, and the elevated levels are associated with adverse pregnancy outcome. These results demonstrate that the human placenta produces and releases CRP, like other placental proteins, mainly into the maternal circulation.
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