Abstract
Haemoglobin variants are inherited disorders of haemoglobin, it is one of the commonest single gene disorder affecting millions of people all over the world, including India. Haemoglobinopathies cause major genetic and public health problems. So, the present study is carried out to find carriers among the healthy individuals to prevent silent transmission of the disorder among the population. Materials and Method: In this study a total of 200 subjects were included amongst the medical students, nurses and nursing students of Silchar Medical College and Hospital for analysis of haemoglobin variants. The study was performed by Horizontal electrophoresis Pherotank by using cellulose acetate membrane and Tris buffer at pH 8.5. Results: Out of 200 subjects studied, 49 subjects had abnormal haemoglobin type. Hb E trait was the most predominant with 31(15.5%) incidence, followed by 9(4.50 %) of HbE/thalassemia, and 6 (3 %) subjects were also found to have HbE disease. It was also seen that thalassemia trait was found in 3 (1.50%) subjects. It was also found that out of total haemoglobin variants 24(48.97%) subjects of HbE trait were anaemic and 7(14.20%) were non-anaemic . 5(10.20%) subjects of HbE disease were anaemic and 1 subject was found to be non- anaemic.
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