Abstract
The present study aim at preparing frusemide in liquid form suitable for oral use. This is achieved through preparing different liquid forms of frusemide. The frusemide liquid is prepared in the following forms: oral solution, syrup and elixir with intensity of 1, 0.4 and 0.8% weight /volume respectively and in combination with potassium carbonate, polysorbate 80, alcohol and phosphate buffer solution of pH8 to dissolve the frusemide in the above mentioned forms. The different forms of the prepared medicine have been stored in glass bottles that can provide protection against light and at 40, 50, 600C for four months. Besides the pH has been checked to decide the period of validity. The results show that the expiration date of frusemide have lasted for 1.8, 1.07 and 1.22 years respectively for the oral solution, the syrup and the elixir. The suspensions of frusemide are formulated in combination with the following: polyvinyl pyrolidine, xanthan gum, the combination of (xanthan gum and sodium carboxymethyl cellulose), the combination of (xanthan: methyl cellulose) and chitosan. The formulas which give suitable release of the drug are chosen for assessment according to the following considerations: The rat of sedimentation and apparent zero order degradation constant at 250C. In conclusion, it is found the best formula is that which includes poly vinylpyrolidine, tween20, glycerol, sorbitol, cocoa syrup and parabens at pH7. the fluidity of this chosen formula is psendoplastic type and its validity has lasted for about three years. The emulsion of frusemide is also prepared extemporaneously by using the commercial frusemide tablets in combination with acacia and olive oil. This should be consumed within 45 days of the date of production.
 Key word: frusemide, elixir, suspension, emulsion.
Highlights
Frusemide which belongs to the suppositories to increase the drug liberation group of loop diuretic is very effective with the use of non-ionic surfactants (solutol of indraining all kinds of oedemas (of cardiac, hepatic or renal origin), in mild or moderateHS 15, cremophor RH60 and montanox 60DF).(3) Frusemide adhesive micro-spheres in hypertension or used in greater doses in acute and chronic renal failure, oliguria. (1)hard gelatin capsules, frusemide granules with dika fat with maize starch and microcapsulesCommerrically available as tablets (20, 40, 80 of frusemide with Acrycoat E30 acrylic and 500mg) and injection (10 and 20 mg/ml) and frusemide oral solution which mentioned in USP. (2) Many studies concered frusemide polymer were prepared and evaluated in man resulting in sustained release. (4) To the patients who have difficulty in swallowing the oral to prepare it in defferent pharmaceutical liquid dosage forms (syrup, elixir, suspension dosage forms as frusemide containing rectal and emulsion) and rectal are offen supplied.Received : 14/4/2008 Accepted : 9 / 7/2008Frusemide is week organic acid such as barbiturates and the sulfonamide
Formulation of frusemide suspension Table (2) shows 6 formulas of frusemide suspension prepared by the following method: frusemide, methyl plus propylparaben, sorbitol and glycerol were Levigated in the mortar with tween[20] and part of prepared dispersions of suspending agents (PVP, xanthan gum, sodium carboxy methyl cellulose, methylcellulose and chitosan) in different concentration as summarized in table (2)
Oral frusemide solution was claimed to produce agreater diuretic with congestive heart failure than tablet so formula I prepared as oral solution containing potassium carbonate which added to increase pH up to 7
Summary
Frusemide which belongs to the suppositories to increase the drug liberation group of loop diuretic is very effective with the use of non-ionic surfactants (solutol of indraining all kinds of oedemas (of cardiac, hepatic or renal origin), in mild or moderateHS 15, cremophor RH60 and montanox 60DF).(3) Frusemide adhesive micro-spheres in hypertension or used in greater doses in acute and chronic renal failure, oliguria. (1)hard gelatin capsules, frusemide granules with dika fat with maize starch and microcapsulesCommerrically available as tablets (20, 40, 80 of frusemide with Acrycoat E30 acrylic and 500mg) and injection (10 and 20 mg/ml) and frusemide oral solution which mentioned in USP. (2) Many studies concered frusemide polymer were prepared and evaluated in man resulting in sustained release. (4) To the patients who have difficulty in swallowing the oral to prepare it in defferent pharmaceutical liquid dosage forms (syrup, elixir, suspension dosage forms as frusemide containing rectal and emulsion) and rectal are offen supplied.Received : 14/4/2008 Accepted : 9 / 7/2008Frusemide is week organic acid such as barbiturates and the sulfonamide. Formulation of frusemide suspension Table (2) shows 6 formulas of frusemide suspension prepared by the following method: frusemide, methyl plus propylparaben, sorbitol and glycerol were Levigated in the mortar with tween[20] and part of prepared dispersions of suspending agents (PVP, xanthan gum, sodium carboxy methyl cellulose, methylcellulose and chitosan) in different concentration as summarized in table (2).
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Schedule a callMore From: Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512)
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