A study on the role of procalcitonin（PCT）and interleukin-6（IL-6）in the early diagnosis and prognostic evaluation of the patients with lumbar intervertebral disc herniation

Abstract

Objective To explore the value of procalcitonin(PCT)and interleukin-6(IL-6)in the early diagnosis and prognostic evaluation of the patientswith lumbar intervertebral disc herniation, and their correlation with the course and lumbar function. Methods 100 patients with lumbar disc herniation(study group)and 35 patients with lumbar non-borne diseases(control group)were collected,their preoperative clinical symptomswere scored on the basis of the lumbar scoring system of Japanese Orthopaedic Association(JOA), the enzyme-linked immunosor-bent assay was applied to determining the content changes of PCT and IL-6 of the two groups, and the linear correla-tion analysis was used to explore the relevance of PCT and IL-6 to the course. Results The contents of the PCT and IL-6 in the study group's serum were respectively(25.13±0.86)ng／L and(10.26±0.36)ng／L, while those in the control group's serum were respectively(223.85±0.61)ng／L and(50.11±1.23)ng／L, both with statistical significance(t＝2.542,2.206,P＜0.01). The IL-6 was positively correlated with the disease duration of the patients with lumbar disc herniation(r＝0.32,P＝0.000), and negatively correlated with their JOA score(r＝-0.45,P＝0.003),and the PCT was positively correlated with the patients'disease duration(r＝0.35,P＝0.001),and nega-tively correlated with their JOA score(r＝-0.53,P＝0.005). Conclusion The PCT and IL-6 have a certain role in the early diagnosis of lumbar disc herniation, and have some relevance to the course of disease and the lumbar func-tion changes. Key words: Intervertebral disc displacement; Procalcitonin; Interleukin-6