Abstract
ABSTRACT A flow-injection chemiluminescence (CL) analysis for determination of pipemidic acid (PPA) is developed. It is based on luminescence produced by Ce(IV)–Na2SO3 CL system sensitized by Tb(PPA)2 3+. The relative chemiluminescence intensity of the Tb3+–PPA–Ce(IV)–Na2SO3 system is proportional to the amount of PPA. The optimized experimental conditions were determined. Accordingly, chemiluminescent method for the determination of PPA is proposed. The linear range and detection limit for PPA are 3.0 × 10−9–8.0 × 10−7 mol/L and 6.7 × 10−10 mol/L, respectively. The familiar excipients such as starch and dextrine do not cause interference. So this method can be applied to the determination of PPA in tablet. The content and recovery of PPA in urine can be directly detected without the pretreatment such as separation. And the mechanism of chemiluminescence is proposed.
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