A STUDY ON SLEEP QUALITY AND SLEEP-DISORDERED BREATHING IN KOREAN PATIENTS WITH LUNG CANCER

Abstract

SESSION TITLE: Sleep Disordered Breathing and Narcolepsy Abstract PostersSESSION TYPE: Original Investigation PostersPRESENTED ON: 10/18/2022 01:30 pm - 02:30 pmPURPOSE: To date, there have been few studies on sleep quality and sleep disordered breathing (SDB) in lung cancer patients. Hypoxia is well known to play a key role in regulating cancer formation and progression. Chronic intermittent hypoxia, a main feature of SDB, has the potential to influence cancer progression. The aim of this study is to investigate the sleep quality and the role of SDB in patients with lung cancer.METHODS: A total of 110 patients who were histologically confirmed with lung cancer were enrolled. All patients were offered home sleep apnea testing (HSAT) and administered a sleep-specific questionnaire. SDB was defined as an apnea-hypopnea index (AHI) of > 5/h. The sleep related symptoms were assessed using the Epworth Sleepiness Scale (ESS), Korean version of the Pittsburgh Sleep Quality Index (PSQI-K), and Korean version of the Insomnia Severity Index (ISI-K).RESULTS: The median ESS, PSQI-K and ISI-K were 5.0 (2.0-8.0), 6.0 (3.0-9.0) and 7.0 (2.0-12.0). About 50% of patients were poor sleepers and 10% had clinical insomnia. The median AHI was 10.3 (7.5-13.2) and the overall prevalence of SDB in the study population was 55.9 %. The prevalence of moderate to severe SDB was 25 %. There were no significant differences in AHI, mean oxygen saturation, and time with oxygen saturation under 90% among the cancer cell type, mutation type, cancer stage, and survival.CONCLUSIONS: Our results show that SDB was prevalent in Korean lung cancer patients. SDB related symptoms were also frequently found. An additional large-scale study is needed to find the association of sleep parameters with the characteristics of lung cancer.CLINICAL IMPLICATIONS: This is a study that investigated the quality of sleep and sleep disordered breathing in actual lung cancer patients, which has not been published much yet. The sleep index of the subject was obtained using the home sleep apnea test device, and various information related to lung cancer (stage, cell type, mutation result, and survival) was included.DISCLOSURES: No relevant relationships by Seiwon Kim SESSION TITLE: Sleep Disordered Breathing and Narcolepsy Abstract Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/18/2022 01:30 pm - 02:30 pm PURPOSE: To date, there have been few studies on sleep quality and sleep disordered breathing (SDB) in lung cancer patients. Hypoxia is well known to play a key role in regulating cancer formation and progression. Chronic intermittent hypoxia, a main feature of SDB, has the potential to influence cancer progression. The aim of this study is to investigate the sleep quality and the role of SDB in patients with lung cancer. METHODS: A total of 110 patients who were histologically confirmed with lung cancer were enrolled. All patients were offered home sleep apnea testing (HSAT) and administered a sleep-specific questionnaire. SDB was defined as an apnea-hypopnea index (AHI) of > 5/h. The sleep related symptoms were assessed using the Epworth Sleepiness Scale (ESS), Korean version of the Pittsburgh Sleep Quality Index (PSQI-K), and Korean version of the Insomnia Severity Index (ISI-K). RESULTS: The median ESS, PSQI-K and ISI-K were 5.0 (2.0-8.0), 6.0 (3.0-9.0) and 7.0 (2.0-12.0). About 50% of patients were poor sleepers and 10% had clinical insomnia. The median AHI was 10.3 (7.5-13.2) and the overall prevalence of SDB in the study population was 55.9 %. The prevalence of moderate to severe SDB was 25 %. There were no significant differences in AHI, mean oxygen saturation, and time with oxygen saturation under 90% among the cancer cell type, mutation type, cancer stage, and survival. CONCLUSIONS: Our results show that SDB was prevalent in Korean lung cancer patients. SDB related symptoms were also frequently found. An additional large-scale study is needed to find the association of sleep parameters with the characteristics of lung cancer. CLINICAL IMPLICATIONS: This is a study that investigated the quality of sleep and sleep disordered breathing in actual lung cancer patients, which has not been published much yet. The sleep index of the subject was obtained using the home sleep apnea test device, and various information related to lung cancer (stage, cell type, mutation result, and survival) was included. DISCLOSURES: No relevant relationships by Seiwon Kim