Prevalence of sleep-disordered breathing in acute coronary syndrome: a systemic review and meta-analysis.

Abstract

This study aimed to review the literature on the prevalence of sleep-disordered breathing (SDB) in patients with acute coronary syndrome (ACS). Relevant studies were searched on PubMed, EMBASE, and Cochrane Library through December 2014. Data were extracted using standardized forms. Pooled prevalence of all SDB (apnea-hypopnea index (AHI)>5), moderate-to-severe SDB (AHI>15), and severe SDB (AHI>30) in ACS patients was calculated using DerSimonian-Laird random-effects model. Sensitivity analysis was performed based on races and diagnostic methods of SDB. A total of 32 studies were included in the present meta-analysis, examining 3360 patients. The meta-analysis indicated that pooled prevalence of all SDB (AHI>5), moderate-to-severe SDB (AHI>15), and severe SDB (AHI>30) in ACS patients were 69% (95% confidence interval (CI)=61, 77%), 43% (95% CI=36, 49%), and 25% (95% CI=17, 33%), respectively. Sensitivity analysis indicated that the pooled prevalence of SDB in Western population was similar to that in Asian population. However, diagnostic methods of SDB seemed to have various impacts on the prevalence of all SDB (AHI>5), moderate-to-severe SDB (AHI>15), and severe SDB (AHI>30). High prevalence of all SDB, moderate-to-severe SDB, and severe SDB was found in ACS patients. It is clinically important to screen for SDB in patients with ACS.