A study on serum ferritin, C-reactive protein, and its correlation with HBA1c in type 2 diabetes mellitus

Abstract

Abstract Introduction: Diabetes mellitus is a multifaceted metabolic disorder with impaired glucose status in the human body relative to insulin deficiency. Resistance to its action causes impaired glucose tolerance and hyperglycemia. Serum ferritin and C-reactive protein (CRP) are acute-phase reactants correlated with glycated haemoglobin (HBA1c) in a diagnosed diabetic patient as chronic inflammatory markers. Aim: The study aimed to study the relationship between HBA1c in diabetes patients and inflammatory markers such as serum ferritin and CRP. Materials and Methods: The study group comprised 106 subjects who met the criteria of type 2 diabetes mellitus, an age group between 30 and 90, involving both genders; inclusion and exclusion criteria were added to the study group. Fasting blood sugar, postprandial blood sugar, HBA1c, urine routine, lipid profile, serum ferritin, and CRP were assessed in all study subjects. Data were statistically analyzed and compared the relationship among HBA1c, serum ferritin, and CRP. Results: In this study, 31.1% constituted the age group between 50 and 60. A total of 51.9% were males. A total of 64.2% were on oral hypoglycaemics, and 18% had urine albumin on examination. On Spearman’s rho correlation between serum ferritin and HbA1c, the r value is 0.011, and the P value is 0.911 having a positive correlation. On Spearman’s rho correlation between CRP and HbA1c, the r value is 0.017, and the P value is 0.865 showing a positive correlation. Conclusion: In this study, inflammatory indicators, including serum ferritin and CRP levels, have a positive correlation with HbA1c values, though statistically not significant, showing higher HbA1c values with elevated serum ferritin and CRP levels. Raised inflammatory markers suggest a chronic inflammatory process in a condition or disease such as diabetes mellitus. By measuring these parameters, we can discover essential aspects of screening, the course of diabetes, its complications, and prevention.