Abstract
BackgroundThis report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-α.MethodsA total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-α of these subjects were investigated.ResultsThe morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-α levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-α levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-α levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-α, while VFA was the independent risk factor of IL-6.ConclusionsThe onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-α and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.
Highlights
This report aims to study the relationship between sarcopenia of elderly in community and inflamma‐ tory factors IL-6 and tumor necrosis factor-α (TNF-α)
The purpose of this study is to investigate the relationship between changes in body composition and the incidence of sarcopenia vs. inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)
Our study found that ALB was an effective predictor of inflammatory factor TNF-α
Summary
This report aims to study the relationship between sarcopenia of elderly in community and inflamma‐ tory factors IL-6 and TNF-α. Bian et al Eur J Med Res (2017) 22:25 that age-related body composition changes, as well as chronic inflammation and proinflammatory factors produced by adipose tissues, are closely related to sarcopenia [2,3,4]; and this inflammatory reaction may play a key role in the occurrence and development processes of sarcopenia. The purpose of this study is to investigate the relationship between changes in body composition and the incidence of sarcopenia vs inflammatory factors interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). M2 in female subjects were adopted as ASMI cut-off values, respectively. A HG strength value
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