Abstract
This study is intended to examine the effects of administration of asymmetric dimethylarginine (ADMA) on the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-10. A total of 30 Wistar adult albino rats were used. Group I was administrated (n=10) with 1mg/kg/day of ADMA, group II (n=10) was administrated with 2mg/kg/day of ADMA and the control group was administrated (n=10) with 0.9% sodium chloride. ADMA was intraperitoneally administrated for 7days. The serum levels of IL-6, TNF-α and IL-10 were measured. There was a significant decrease in the levels of TNF-α, IL-6 and IL-10 in group I compared with that of the control group (p<0.001). There was also a significant decrease in the levels of IL-10 in group II compared with that of the control group (p<0.05) but the increase was much more distinct in the levels of IL-6 and TNF-α (p<0.001). When comparing the groups by the doses given, no difference between the levels of IL-6 and IL-10 in groups I and II (p>0.05) was observed; the levels of TNF-α in group II were significantly lower than those of group I (p<0.05). A significant decrease in the serum levels of inflammatory cytokines IL-6, TNF-α and IL-10, after administration of 1mg/kg/day and 2mg/kg/day of ADMA, indicates that ADMA has an effect on inflammation. Increase in ADMA levels in the rats shows that the effects of inflammatory cytokines were suppressed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
