Abstract
Background: Escherichia coli is the commonest organism causing urinary tract infection in women and children especially in those with uncom- plicated infections. It has been traditionally described Serotypes of Escherichia coli were consistently associated with Uropathogenicity and designated as Uropathogenic Escherichia coli.It is now recognized that a subset of fecal Escherichia coli can be colonized in the peri-urethral area, enter the urinary tract and cause symptomatic disease. These are currently defined as Uropathogenic Escherichia coli. The aims & objectives are to the isolation of Escherichia coli in Urinary tract infection. 2. To determine the prevalence of Serum resistant Uropathogenic Escherichia coli. 3. To compare antimicrobial efficacy in Serum resistant and Serum sensitive Uropathogenic Escherichia coli. Subjects & Methods: An observational study was conducted on 100 patients and urine samples collected from suspected and suffering from urinary tract infection. Study period from August 2018 to July 20019 attending General medicine OP in Hospital. Escherichia coli were isolated and identified by conventional techniques Mackie & Mc Cartney. The strains were subjected to multiple drugs to study serum resistance and sensitivity. Results: From 100 urine samples 71 Uropathogenic, 18 males & 53 females. 40% Sero-resistant and 60% Sero-sensitive among them 2 to 18 years males and > 40 years females resistant, above 40 years males and 19 to 40 years females are sensitive to multiple antibiotics. Conclusion: it emphasizes Serum resistance is an important virulence factor, It may lead to pyelonephritis and septicemia. Serum resistant E. coli are multiple drug-resistant, so the present study formulating guidelines for planning effective treatment and Periodic surveillance to monitor resistance.
Highlights
Escherichia coli is the commonest organism causing urinary tract infection in women and children especially in those with uncomplicated infections
It is recognized that there is a subset of fecal Escherichia coli that can be colonized in the periurethral area, enter the urinary tract and cause symptomatic disease
Common virulence factors are Surface hydrophobicity, Colonization factor, Capsule, Serum resistance, Resistance to phagocytosis, Mannose resistant haemaglutination (MRHA), Mannose sensitive haem-aglutination (MSHA), Haemolysins, Enterotoxins, Siderophores, production of Alpha haemolysis, Colicins, Aerobactin, Cytotoxic necrotizing factor and ability to adhere uroepithelial cell. [1,3,4] These are currently defined as Uropathogenic Escherichia coli
Summary
Escherichia coli is the commonest organism causing urinary tract infection in women and children especially in those with uncomplicated infections It has been traditionally described Serotypes of Escherichia coli were consistently associated with Uropathogenicity and designated as Uropathogenic Escherichia coli.It is recognized that a subset of fecal Escherichia coli can be colonized in the peri-urethral area, enter the urinary tract and cause symptomatic disease. These are currently defined as Uropathogenic Escherichia coli. Serum resistant E. coli are multiple drug-resistant, so the present study formulating guidelines for planning effective treatment and Periodic surveillance to monitor resistance
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