Abstract
Problem statement: Metallo Beta Lactamse (MBL) producing bacteria is gradually increasing throughout the globe. There is no report of MBL producing bacteria from the city of Kolkata so far although it is a very big metropolice city in India. Thus this study was aimed to investigate the impact of this highly virulent group of bacteria in this city. Approach: In this experiment we studied the prevalence, following standard methods of isolation and identification techniques of these bacteria from clinical materials and also studied some characteristics and clinical data in relation to MBL producing bacterial infections in this locality. Results: It was seen that a high prevalence of MBL producing bacteria was present in this city and there were many differences between MBL producing bacterial infection in comparison to the MBL non producing bacterial infection, particularly in relation to age distribution, sex predominance, mortality rate, hematological changes, nature of primary diseases in which infection occurred. There were also some electron microscopic morphological alterations in MBL positive bacterial isolates. Conclusion: This study confirmed significant occurrence of MBL producing bacterial infections in Kolkata showing distinct clinic microbial changes in this type of infection.
Highlights
In India treatment of intensive care unit patients is becoming difficult due to upsurge of carbapenemases in Gram negative bacteria belonging to Enterobacteriaceae
If the zone of inhibition of Imipenem + EDTA discs compared to Imipenem alone is greater than 7 mm, the test organism can be considered as Metallo Beta Lactamase (MBL) producing
General prevalence of MBL positive bacteria in Kolkata: Prevalence of MBL producing bacteria was studied and it was seen that 41.2% bacteria were MBL positive among all isolates
Summary
If the zone of inhibition of Imipenem + EDTA discs compared to Imipenem alone is greater than 7 mm, the test organism can be considered as MBL producing. Isolated MBL positive bacteria: One strain of MBL producing Pseudomonas aeruginosa were selected to see any structural difference comparing to international strain. Difference between MBL positive and MBL negative that there is no sex predominance in this group, male bacteria in relation to the patients suffering from and females were both showing 50% of occurrence.
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