Abstract
Objective: To study the effect of Cimetidine (H2 receptor antagonist) in combination with Glipizide (Sulfonylurea) on the blood sugar level in rabbits.
 Methods: Six albino rabbits were taken for the study. Glipizide was administrated to each rabbit as a single drug therapy on day 1 and it was co-administrated with Cimetidine to each rabbit as a combinational drug therapy on day 7. Cimetidine was administrated to each rabbit from day 2 to day 6 as single drug therapy. Blood sugar levels were estimated on day 1 and on day 7 at 0, 1, 2, 4, and 6 h.
 Results: The mean blood sugar level readings at 0, 1, 2, 4 and 6 h on day 1 were 90.4, 69.4, 62.9 and 65.7 mg% and on day 7 were 89.4, 74.8, 65.5, 56.4 and 61.2 mg % respectively. When mean blood sugar level on day 1 and day 7 was considered, there was a significant reduction in blood sugar level at 1, 2, 4 and 6 h and there was no significant fall in blood sugar level at 0 hour after co-administration of Glipizide and Cimetidine.
 Conclusion: Cimetidine, when co-administered with Glipizide, significantly increases the hypoglycaemic action of Glipizide.
Highlights
Drug-drug interactions may occur when more than one drug is administered in a patient to treat a single ailment or multiple ailments
When mean blood sugar level on day 1 and day 7 were considered, there was a significant reduction in blood sugar level at 1, 2, 4 and 6 h and there was no significant fall in blood sugar level at 0 hour after co-administration of Glipizide and Cimetidine
Some studies have revealed the existence of number of drug interactions involving the inhibition of hepatic microsomal drug metabolism by drugs containing aromatic nitrogenous basis such as imidazole structure [4]
Summary
Drug-drug interactions may occur when more than one drug is administered in a patient to treat a single ailment or multiple ailments. These concomitantly used drugs may either cause pharmacodynamic or pharmacokinetic types of interactions. The net result of both types of interactions is the alteration in the therapeutic effect of either or both the drugs. Patients with such diseases will often need to be administered drugs for treatment of other coexisting diseases, either for a short period or lifelong. There is a possibility of occurrence of interactions between drugs, resulting in either reduced or enhanced effects of any of the drugs. Monitoring and readjustment of the dose/s is often necessary to optimize treatment
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