Abstract
Background Several conditions have been known to causetransient congenital hypothyroidism (TCH), including transplacental passage of TSH receptor blocking antibody (TSBAb), maternal antithyroid drug usage, iodine deficiency, iodine excess, fetal prematurity and inactivatingDUOX2mutations. However, the underlying etiology of TCH is not determined in some cases. In this study, we conducted the first systematic investigation on the etiology of TCH, using screening population-based cohort in Niigata Prefecture, Japan.
Highlights
Several conditions have been known to causetransient congenital hypothyroidism (TCH), including transplacental passage of TSH receptor blocking antibody (TSBAb), maternal antithyroid drug usage, iodine deficiency, iodine excess, fetal prematurity and inactivatingDUOX2mutations
The underlying etiology of TCH is not determined in some cases
Between April 2003 and March 2009, 148,100 newborns were screened for CH in Niigata prefecture, and 159 patients were considered positive for CH
Summary
Several conditions have been known to causetransient congenital hypothyroidism (TCH), including transplacental passage of TSH receptor blocking antibody (TSBAb), maternal antithyroid drug usage, iodine deficiency, iodine excess, fetal prematurity and inactivatingDUOX2mutations. A study of the etiology of transient congenital hypothyroidism in Niigata Prefecture, Japan Keisuke Nagasaki1*, Satoshi Narumi2, Kiyomi Abe2, Tadashi Asami3, Hidetoshi Sato1, Yohei Ogawa1, Toru Kikuchi1, Tomonobu Hasegawa2, Akihiko Saitoh1
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