Abstract
Oral administration (100 mg/kg) of the miticide ovex (p-chlorophenyl p-chlorobenzene-sulfonate) caused a decrease in the hexobarbital sleeping time of rats. Administration of this same dosage of ovex resulted in a significant decrease in the toxicity of orally administered parathion (100 mg/kg) to rats.The changes in rats noted in conjunction with the increased resistance to organophosphate toxicity in vivo were an increased liver size, an increased rate of in vitro α-naphthyl acetate hydrolysis by the 9000 × g liver supernatant.The hexane-extractable organophosphate detected in the liver of the ovex-pretreated rats was significantly lower than the hexane extractable organophosphate found in the liver of the control rats.
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