A Study Of The Clinical and Biochemical Profile Of Acute Viral Hepatitis

Abstract

Aim: This study was performed to compare the clinical, biochemical and etiological properties of acute viral hepatitis (AVH) and to compare clinical and laboratory parameters of faeco-oraly transmitted hepatitis: hepatitis A+ hepatitis E (A+E) with hematologicaly transmitted: hepatitis B, C, D (B+C+D) hepatitis. Material and Methods: Biochemical and clinical data were collected from 40 patients with AVH. They were tested for hepatitis B surface antigen (HBsAg), IgM anti-Hepatitis A virus (HAV), IgM anti-HBc (hepatitis B core antigen), IgM anti- hepatitis D (HDV), or IgM anti- hepatitis C (HCV). Finally X 2 test was used to analysis of data. Results: Most patients were young adults and presented with jaundice and other constitutional features, although anicteric hepatitis was also seen. Hepatitis E was the most common AVH. Malaise, fever, icterus, vomiting and nausea were significantly more in Hepatitis A +E compared with Hepatitis B + C in acute course. Serum bilirubin both total and direct was significantly elevated in hepatitis A + E compared with Hepatitis B + C in acute course. Conclusions: Hepatitis E was the most common AVH .There were some differences in clinical and laboratory findings regarding to the etiology but it does not necessarily distinguish one cause of hepatitis from another.