“A study of Serum levels of LDH and ALP in carcinoma breast: An Observational study”

Abstract

Background:- Breast Cancer is one of the major surgical problems in India particularly among the younger women. Unfortunately, most breast cancers do not produce any symptoms until the tumors are either too large to be removed surgically or cancerous cells have already spread to other tissues i.e. metastasis has taken place. Therefore, there is a need for noninvasive and sensitive methods to detect growths small in size which escape routine examination .There is, therefore, need of simple investigations, which can be easily assayed, are less expensive and can detect metastasis. Aims And Objectives: To study the serum levels of LDH and ALP in cases of breast lesions and to evaluate whether their levels are significantly higher in cases of breast malignancies as compared to cases of benign breast lesions Material And Methods:- A total number of 160 subjects were studied, comprising of 80 cases of benign breast lesions and 80 Breast cancer subjects. Breast cancer subjects were further divided depending on stage of the cancer. Serum levels of LDH and ALP were estimated in all the subjects. RESULT:- The present observational study has shown a significant elevation in serum levels of LDH and ALP in cases of carcinoma Breast as compared to benign breast lesions. These levels raised significantly with severity (stage) of carcinoma Breast. Conclusion:- Serum LDH and ALP may serve as biomarkers in carcinoma breast and may help in early detection of progression of the disease. These enzymes can be easily assayed in laboratories that do not have sophisticated technologies.