Abstract
Background: Thyroid nodule is a common presentation and requires structured diagnostic approach to ascertain the risk of malignancy and determine appropriate management. The aims of this randomized study is to evaluate potentiate role of thyroglobulin (Tg), thyroid stimulating hormone (TSH), and size of nodule as preoperative indicators of primary well differentiated thyroid cancer (WDTC).Methods: This is a retrospective Study of 70 cases of colorectal carcinoma analysing incidence, clinicopathological features and outcome after different therapies including surgery, radiotherapy and chemotherapy.Results: Preoperative Tg with cut-off >36 ng/ml is a significant predictor of malignancy. Anti-Tg Ab with cut-off of 3 IU/ml along with TSH are independent predictors of malignancy.Conclusions: FNAC and Frozen section study has specificity of 67 and 75% and sensitivity of 74 and 80%, respectively. Accuracy of FNAC and frozen section study are 71 and 73%, respectively and preoperative thyroglobulin (Tg) with cut-off >36 ng/ml is a significant predictor of malignancy.
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