Abstract
Altered platelets have been reported in patients with diabetes mellitus and MS has been considered asa ‘prothrombotic state’ with enhanced platelet reactivity. They have been associated with increased riskof vascular complications in these patients. Platelet indices correlate with functional status of plateletsand is an emerging risk factor of vascular complications in diabetes and MS. The study was undertakento know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus and MS. Resultsof our study may lay a foundation for a discovery of new approaches for prevention and treatment ofcardiovascular complications in MetS and DMT2 in early stages of metabolic disorders in patients. MetS isa proinflammatory and prothrombotic state, characterized by alteration of platelet indices. Plateletcrit wasshown to be a significant biomarker along with other parameters, including waist circumference,SBP, andserum triglyceride levels. Platelet activation causes high risk of cardiovascular complications in MetS. T2DM is associated with the changes in the intra cellular signaling systems regulating platelet functions.
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