Abstract
Background: Microalbuminuria is a key risk factor for several cardiovascular diseases and renal impairment. This is particularly true for diabetics, in whom it is common and can be used to predict the development of complications. Materials and Methods: A prospective observational study. Participants were divided into 3 different groups: Group I – Control (n = 20), Group II – Patients with type II diabetes mellitus (n = 300), Group III – Diabetic patients with retinal changes (n = 50). Medical history, physical examination, complete blood count, ECG, chest X-ray and urine examination, tests for microalbuminuria, echocardiogram and fluorescein angiography were performed. Results: Mean age of patients in group I and II were 57.60 ± 11.07 and 57.04 ± 11.57 years respectively. 46% participants were taking oral anti diabetic agents. Out of 300 patients of type 2 DM–64% were micral test negative and 36% were micral test positive. In group III, 32% were normoalbuminuric and 68% were microalbuminuric. Positive correlation was found between duration of DM and presence of microalbuminuria. Serum cholesterol and serum triglycerides level were more in microalbuminurics than normoalbuminurics and the difference was statistically significant while the difference in the levels of serum LDL and serum HDL was statistically insignificant between two groups. 55.6% of the diabetics with microalbuminuria were hypertensive. Conclusion: Microalbuminuria can be considered as one of the predictive factors for overt nephropathy and various complications of DM. Thus, detection of microalbuminuria at an early stage may help in preventing the diabetic complications.
Highlights
Diabetes mellitus (DM), the most common endocrine disease, is a metabolic syndrome, characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative deficiency in insulin secretion and/or insulin action
6% patients were more than 70 years of age. 50 patients of type 2 DM were having retinal complications (Group III)
The present study was conducted on 20 - age, sex, and body mass index (BMI) matched healthy controls (Group I) and 300 patients of type 2 diabetes mellitus (Group II)
Summary
Diabetes mellitus (DM), the most common endocrine disease, is a metabolic syndrome, characterized by chronic hyperglycemia and disturbances of carbohydrate, fat and protein metabolism associated with absolute or relative deficiency in insulin secretion and/or insulin action. Diabetic patients with poor glycemic control and longer duration of disease are more prone to develop various complications. A correlation may exist between various complications of diabetes mellitus like microalbuminuria and overt nephropathy, retinopathy, ischemic heart disease, cerebral stroke etc and duration of diabetes and genetic predisposition. The presence of microalbuminuria, which can be detected by a simple, quick and noninvasive test, may be a predictor of vascular complications in patients with diabetes mellitus. Microalbuminuria is a key risk factor for several cardiovascular diseases and renal impairment. This is true for diabetics, in whom it is common and can be used to predict the development of complications. Detection of microalbuminuria at an early stage may help in preventing the diabetic complications
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
