A study of liver functions in metabolic syndrome and Type 2 diabetes mellitus

Abstract

Introduction: Diabetes mellitus is a metabolic disease known by chronic hyperglycemia which results from defective insulin action and secretion. Metabolic syndrome consists of a constellation of metabolic abnormalities that confer increased risk of diabetes mellitus. The aim of the present study was to find out if there is any liver function impairment in patients with metabolic syndrome and type 2 diabetes mellitus. Materials and Methods: 50 controls, 50 individuals with metabolic syndrome and 50 individuals with type 2 diabetes mellitus were selected by purposive sampling technique. Serum levels of ALT, AST, ALP, total bilirubin and albumin were estimated in controls and cases. Results: The mean values of serum ALT,AST,ALP, total bilirubin were significantly increased (p<0.001) and serum albumin levels were significantly decreased (p<0.001) in cases compared to controls. Conclusion: Liver functions are impaired in patients with metabolic syndrome and type 2diabetes mellitus when compared to controls.