Abstract

Members of the Protozoan Order Kinetoplastida are characterized by the presence of a unique organelle called the kinetoplast. The kinetoplast, a Feulgen-positive granule, is an integral part of the single mitochondrion of these flagellates and contains a large amount of deoxyribonucleic acid (DNA, Fig. 1). Dyskinetoplasty, an apparent disruption of the kinetoplast DNA (kDNA), occurs spontaneously at low frequency in different species of Kinetoplastida, and can be induced experimentally with various DNA-complexing compounds (1). Ultrastructural studies of the equine pathogen Trypanosoma equinum, a naturally occuring totally dyskinetoplastic species, were undertaken to determine the possible presence, morphology, and location of kDNA within the mitochondrion.

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