A study of histopathological features of upper gastrointestinal tract endoscopic biopsies in a tertiary care centre

Abstract

Upper gastrointestinal tract (UGIT) comprises of esophagus, stomach and duodenum till the second part. Diseases affecting this region include inflammatory lesions, dysplasias, benign neoplasms and malignancies. Endoscopic biopsy and histopathological examination is considered as gold standard for gastrointestinal disorders. Endoscopic biopsy aids in early diagnosis of malignancy and better patient management. Present study was conducted with an aim of studying various histopathological features of endoscopic biopsies obtained from the UGIT.This study was a retrospective study of all UGIT endoscopic biopsies that were received from January 2015 to April 2020. Archived hematoxylin and eosin stained slides were retrieved and reviewed for various morphological abnormalities.During the study period 70 endoscopic biopsies from the UGIT were received. The incidence of malignancy was 74% and non-neoplastic lesions amounted to 26% of the biopsies. Biopsies from the esophagus (63%) constituted the major portion, followed by stomach (34%) and duodenum (3%).In our study incidence of malignancy outnumbered the non-neoplastic conditions. Esophagus was the most commonly biopsied site and squamous cell carcinoma of middle part of the esophagus was the most common malignancy. Inflammatory conditions constituted major part of the non-neoplastic lesions.