Abstract
Abnormal uterine bleeding(AUB) is one of the most common gynaecological problems, which accounts for about 33% of out patient referrals. It is a debilitating condition with high direct and indirect costs. AUB is considered as a cause of significant health care burden for women, their families and society as a whole. To study the various histomorphological patterns of endometrium in AUB. This is a retrospective study done in Department of Pathology, tertiary care hospital, JJMMC Davangere for a period of 2 years from January 2016 to December 2017. 212 cases of endometrial biopsies were reviewed in AUB. The slides were obtained from departmental archives and clinical data from the histopathological forms. The data was entered and interpreted in Microsoft Excel and the analysis was done in percentages and proportions and was represented in tables, graphs and pie charts wherever necessary. A total of 212 cases were analysed and the age of females ranged from 20-62 yrs. The most common histomorphological pattern was Endometrial Hyperplasia without atypia in 43.0% of cases followed by Secretory endometrium in 15.6% of cases. Proliferative endometrium was seen in 14.6% of cases and Disordered proliferative endometrium was seen in 14.2% of cases. There were also 2 cases with Simple atypical hyperplasia. The cause of AUB can be identified by the histopathological study of endometrial curettages and biopsies. This helps to plan for successful management of the females presenting with AUB.
Highlights
Abnormal uterine bleeding(AUB) is one of the most common gynaecological problems, which accounts for about 33% of out patient referrals
The aim of this study is to study the various histopathological patterns in the endometrial biopsy of patients presenting with abnormal uterine bleeding
The most frequent histomorphological pattern was Endometrial Hyperplasia without atypia found in 91 patients (43.0%) followed by secretory endometrium in 33 patients (15.6%)
Summary
Abnormal uterine bleeding(AUB) is one of the most common gynaecological problems, which accounts for about 33% of out patient referrals It is a debilitating condition with high direct and indirect costs. Conclusion: The cause of AUB can be identified by the histopathological study of endometrial curettages and biopsies. This helps to plan for successful management of the females presenting with AUB. Chronic AUB is “ bleeding from the uterine corpus that is abnormal in duration, volume, and/or frequency and has been present for the majority of the last 6 months.” 1 The causes of Abnormal uterine bleeding may be physiological, pathological or pharmacological. 2 It is associated with any type of endometrium ranging from normal endometrium to hyperplasia, irregular ripening, chronic menstrual irregular shedding and atrophy. It may be due to fibromyoma, adenomyosis, endometrial polyp, ovarian tumor, pelvic inflammatory disease (PID), endometrial hyperplasia, endometrial carcinoma, hormonal imbalance (like hypothyroidism), or hypothalamic-pituitary diseases
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