Abstract
This chapter analyzes the pharmacokinetics and metabolism of metronidazol in athletic and nonathletic groups of young adults and to gain more accurate knowledge about the mechanism of the exercise induced changes. In an experiment described in the chapter, the chemotherapeutic agent was metabolized mainly by the microsomal enzyme system and excreted via the kidney. There was a significant intergroup difference in peak metronidazol concentration and in its volume of distribution. As these parameters are independent from the microsomal enzyme system, the kinetic changes may be attributed to the exercise-induced differences in body composition: to an increase in lean body mass and an increased ratio of muscle mass to adipose tissue in the trained group. In the metabolism of metronidazole, an intergroup difference could not be demonstrated. It can be concluded that the reported changes in the kinetics found in the athletes are caused by an increased metabolization rate, by the differences in body composition.
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