Abstract
To conquer the worldwide outbreak of COVID-19 virus, a large number of studies have been carried out on COVID-19 infection, transmission and treatment. However, few studies have been conducted from the perspectives of circRNA and lncRNA, which are known to be involved in regulating many life activities, such as immune tolerance and immune escapes, and hence may provide invaluable information in the emerging COVID-19 infection and recurrence. Moreover, exosomes has been reported to play an important role in COVID-19 recurrence, and thus may interact with the expression of circRNA and lncRNA. In this work, we sequenced circRNA, lncRNA and mRNA from recurrent COVID-19 patients and healthy people, and compared the differences. GO and KEGG enrichment analysis show that differentially expressed circRNA and lncRNA are mainly involved in the regulation of host cell cycle, apoptosis, immune inflammation, signaling pathway and other processes. The comparison to exosomes related databases shows that there are 114 differentially expressed circRNA, and 10 differentially expressed lncRNA related to exosomes. These studies provide reference for exploring circRNA and lncRNA to study the infection mechanism of COVID-19, their diagnostic and therapeutic values, as well as the possibility to employ them as biomarkers.
Highlights
Since December 2019, the Novel Coronavirus, abbreviated as COVID-19, has spread across the globe
Researchers have been popularizing the basic knowledge of coronavirus, and introducing the characteristics of coronavirus, the diseases caused by coronavirus, and COVID-19 infection clinical diagnosis, source tracing, characteristics and development trend of infection in different r egions[1,2,3,4,5,6,7,8,9,10,11]
Through comparison and analysis of the positive and healthy groups in accordance with the above standard, as shown in Fig. 1, we found a total of 570 circRNA that have difference, among which 155 are up-regulated and 415 are downregulated; and 898 lncRNA that have difference, in which 414 are up-regulated and 484 are down-regulated; and 476 mRNA that have difference, in which 98 are up-regulated and 378 are down-regulated
Summary
Since December 2019, the Novel Coronavirus, abbreviated as COVID-19, has spread across the globe. Ghafouri-Fard, et al reviewed the ACE2 and COVID-19 infection, and clarified in details the important role of ACE2 and recent research progress in this a rena[18]. Et al pointed out that two potential drugs that can inhibit COVID-19 could be filtered out by in vitro experiment of the Wuhan Institute of Virology. The last, which is the most important, is the study of COVID-19 medical treatment. Et al reported the successful treatment of severe COVID-19 infection with Clazakizumab in a heart transplant patient[23]. Based on the knowledge accumulated from previous research, Liu, et al proposed a possible emergency prevention and treatment regimen for severe acute respiratory infection caused by COVID-1926. Et al introduced angiotensin receptor blockers in the treatment of diseases caused by COVID-1929. The treatment using remdesivir, favipiravir and other drugs was the focus of the analysis by r esearchers[30,31]
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