Abstract
Objective The aim of this study was to evaluate serum apelin levels in Egyptian pediatric patients with chronic kidney disease (CKD) and its relation with markers of endothelial dysfunction, cardiac functions, and nutritional status. Patients and methods Our study comprised 66 clinically stable CKD patients and 20 normal healthy volunteers. We performed enzyme-linked immunosorbent assay technique to assess serum levels of apelin and; vascular cell adhesion molecule-1 (VCAM-1). Cardiac functions were assessed by means of echocardiogram. Nutritional analysis was achieved with the 24 h dietary recall method. Results VCAM-1 levels were significantly elevated in children with CKD as compared with controls. No difference in apelin mean levels was found between patients and controls. VCAM-1 levels positively correlated with interventricular septum thickness, and inversely correlated with both vitamin B1 and magnesium intake determined by means of food analysis. Conclusion Children with CKD had endothelial dysfunction that was detected by means of elevated levels of serum VCAM-1, which showed a relation to height and weight of the patients, as well as a relation to interventricular septum thickness and with magnesium and vitamin B1 intake. However, there was no difference in serum apelin levels between the patients and controls and no relation was found with VCAM-1.
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