Abstract
AbstractNew pyrrolo[2,3‐d]pyrimidines that have aryl groups at the 2‐, 4‐, and 6‐positions were prepared by the arylation reaction of 4‐chloro‐7‐methyl‐2‐(methylthio)‐6‐phenylpyrrolo[2,3‐d]pyrimidine (6) and the corresponding arylboronic acid under Suzuki–Miyaura conditions followed by a second arylation under Liebeskind–Srogl cross‐coupling conditions. A parallel study that began with the C‐2 chemoselective arylation of 6 under Liebeskind–Srogl conditions followed by a Suzuki–Miyaura coupling at C‐4 was carried out, and the results of each route were compared. All of the tranformations were performed under microwave irradiation.
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