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Abstract
AbstractThe syntheses of new heterocyclic isoxazoline amino acids are described based on a domino Michael addition/nitrile oxide formation/[3+2] cycloaddition approach. Chelated amino acid ester enolates can be added to nitroalkenes, and the generated nitronates are directly converted into nitrile oxides. These can be trapped intramolecularly by an alkene as a dipolarophile. The alkene can be introduced either via the nitroalkene or via the chelated enolate. Therefore, different types of heterocyclic amino acids can be obtained in a simple one‐pot protocol.
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