Abstract
Objective: The aim of present work was to mask the bitter taste of sildenafil citrate by preparing drug resin complex (DRC) and develop sildenafil citrate 100 mg effervescent tablets.
 Methods: Sildenafil citrate and kyron T134 complexes were prepared at different conditions and evaluated for taste and drug loading. Optimized DRC was use to formulate the dispersible tablet by direct compression technique. A 32 full factorial design was use to study the effect of effervescent agent (X1) and croscarmellose sodium (X2) on dispersion time (Y1) and wetting time (Y2). Factorial batches were also evaluated for thickness, hardness, content uniformity, friability, in vitro drug release and stability studies. Multiple linear regression analysis, ANOVA and graphical representation of the influence factor by 3D plots were performing by using sigma plot 11.0. A Check point batch was design according to the results of desirability value and evaluated for all the parameter
 Results: FT-IR study confirm that sildenafil citrate and kyron T134 were compatible with each other. Among the various DRC batch B29 was found with less bitter and give a more drug loading. Checkpoint batch showed no significance difference between predicted value and actual value for dispersion time and wetting time and it was found stable during stability study.
 Conclusion: Sildenafil citrate bitter tast was masked by kyron T134 and full factorial design result was indicate that independent variables have significant effect on dependent variables
Highlights
Oral route of drug administration is the most appealing route for the drug delivery but the numbers of orally administered drugs are bitter taste and that creates an unpleasant feeling in the mouth.it is necessary to mask the bitterness for enhancing patient acceptability [1, 2]
FT-IR study confirm that sildenafil citrate and kyron T134 were compatible with each other
Checkpoint batch showed no significance difference between predicted value and actual value for dispersion time and wetting time and it was found stable during stability study
Summary
Oral route of drug administration is the most appealing route for the drug delivery but the numbers of orally administered drugs are bitter taste and that creates an unpleasant feeling in the mouth.it is necessary to mask the bitterness for enhancing patient acceptability [1, 2]. Ion exchange resins are inexpensive and used to develop a simple, rapid and cost-effective method of taste masking. Ion exchange resins are cross-linked polymers containing salt forming groups in repeating positions on the polymer chain, have an affinity for oppositely charged counter ions, adsorbing the ions into the polymer matrix. Several ion-exchange resins have been developed for oral administration. Kyron T134 is a derivative of cross-linked polyacrylic polymer used to mask the bitter of medicines. It is a weak acid derivative of acrylic acid cross-linked polymer having carboxylic acid functional group, which contains K+ionic form [3, 4]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call